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Digital microfluidics: A promising technique for biochemical applications
He WANG, Liguo CHEN, Lining SUN
Frontiers of Mechanical Engineering 2017, Volume 12, Issue 4, Pages 510-525 doi: 10.1007/s11465-017-0460-z
Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application potential in the areas of automation and miniaturization. In DMF, discrete droplets containing samples and reagents are controlled to implement a series of operations via electrowetting-on-dielectric. This process works by applying electrical potentials to an array of electrodes coated with a hydrophobic dielectric layer. Unlike microchannels, DMF facilitates precise control over multiple reaction processes without using complex pump, microvalve, and tubing networks. DMF also presents other distinct features, such as portability, less sample consumption, shorter chemical reaction time, flexibility, and easier combination with other technology types. Due to its unique advantages, DMF has been applied to a broad range of fields (e.g., chemistry, biology, medicine, and environment). This study reviews the basic principles of droplet actuation, configuration design, and fabrication of the DMF device, as well as discusses the latest progress in DMF from the biochemistry perspective.
Keywords: digital microfluidics electrowetting on dielectric discrete droplet biochemistry
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 679-692 doi: 10.1007/s11684-021-0866-1
Keywords: metabolic reprogramming potential of electron transfer cell proliferation aerobic glycolysis cancer metabolism
Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 255-263 doi: 10.1007/s11684-012-0227-1
Keywords: primary biliary cirrhosis ursodeoxycholic acid Chinese biochemical response therapeutic efficacy
Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine
Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 90-99 doi: 10.15302/J-FASE-2015045
Keywords: myostatin transforming growth factor-β family skeletal muscle metabolic disorders chromatography mass spectrometry metabonomics
Elena SMIRNOVA, Alexander GUSEV, Olga ZAYTSEVA, Olga SHEINA, Alexey TKACHEV, Elena KUZNETSOVA, Elena LAZAREVA, Galina ONISHCHENKO, Alexey FEOFANOV, Mikhail KIRPICHNIKOV
Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2, Pages 132-138 doi: 10.1007/s11705-012-1290-5
Keywords: multiwalled carbon nanotubes plants electron microscopy
Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU
Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2, Pages 226-238 doi: 10.1007/s11783-013-0582-4
Keywords:
cadmium (Cd)
low-Cd cultivar
pakchoi (
Tian Zhiyong,Tu Xiang,Song Yonghui,Xin Wang,Li Fayun
Strategic Study of CAE 2013, Volume 15, Issue 3, Pages 80-87
The lab-scale and pilot-scale physical-chemical and biochemical combinedremoval performance could be improved significantly by reasonable coupling of physical-chemical and biochemical
Keywords: refractory dry-spun acrylic fiber wastewater physical-chemical biochemical combined treatment
BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES
Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, Pages 82-97 doi: 10.15302/J-FASE-2021404
Keywords: biochemical insecticide / bioinsecticide / microbial bioinsecticides / plant-incorporated protectant
Development of a seismic design method based on response spectra for building structures
ZHOU Xiyuan, YU Ruifang
Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2, Pages 129-141 doi: 10.1007/s11709-007-0014-2
Keywords: generalization classical damping mode-superposition response calculation formula damping theory
Temporal changes in the characteristics of algae in Dianchi Lake, Yunnan Province, China
Ruixia SHEN,Chunyan TIAN,Zhidan LIU,Yuanhui ZHANG,Baoming LI,Haifeng LU,Na DUAN
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3, Pages 266-275 doi: 10.15302/J-FASE-2015064
Keywords: algal blooms temporal change biochemical property biodiversity hydrothermal liquefaction
Confining pressure effect on dynamic response of high rockfill dam
Xuexing CAO, Yunlong HE, Kun XIONG,
Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1, Pages 116-126 doi: 10.1007/s11709-010-0014-5
Keywords: confining pressure effect high rockfill dam dynamic response Hardin-Drnevich constitutive model
Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3, Pages 593-606 doi: 10.1007/s11465-021-0636-4
Keywords: topology optimization solid isotropic material with penalization transient response aggregation function
Dynamic response of precast segmental bridge columns under heavy truck impact
Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3, Pages 327-349 doi: 10.1007/s11709-023-0911-z
Keywords: precast segmental bridge columns heavy truck collision dynamic response
Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2, Pages 221-236 doi: 10.1007/s11705-021-2061-y
Keywords: data-driven modeling pharmaceutical organic synthesis Lasso regression dynamic response surface methodology
Tangchun Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 816-819 doi: 10.1007/s11684-020-0823-4
Title Author Date Type Operation
Digital microfluidics: A promising technique for biochemical applications
He WANG, Liguo CHEN, Lining SUN
Journal Article
Potential of electron transfer and its application in dictating routes of biochemical processes associated
Journal Article
Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis: a 2-year follow-up study
Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan
Journal Article
Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine
Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI
Journal Article
Uptake and accumulation of multiwalled carbon nanotubes change the morphometric and biochemical characteristics
Elena SMIRNOVA, Alexander GUSEV, Olga ZAYTSEVA, Olga SHEINA, Alexey TKACHEV, Elena KUZNETSOVA, Elena LAZAREVA, Galina ONISHCHENKO, Alexey FEOFANOV, Mikhail KIRPICHNIKOV
Journal Article
Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation
Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU
Journal Article
Research on physical-chemical and biochemical combined technology in the treatment of refractory petrochemical
Tian Zhiyong,Tu Xiang,Song Yonghui,Xin Wang,Li Fayun
Journal Article
BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES
Journal Article
Development of a seismic design method based on response spectra for building structures
ZHOU Xiyuan, YU Ruifang
Journal Article
Temporal changes in the characteristics of algae in Dianchi Lake, Yunnan Province, China
Ruixia SHEN,Chunyan TIAN,Zhidan LIU,Yuanhui ZHANG,Baoming LI,Haifeng LU,Na DUAN
Journal Article
Confining pressure effect on dynamic response of high rockfill dam
Xuexing CAO, Yunlong HE, Kun XIONG,
Journal Article
Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme
Journal Article
Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis
Journal Article